Endocrine Abstracts

Introduction: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the chromaffin tissue characterised by catecholamine excess. Cardiovascular complications, such as hypertensive crisis and catecholamine-induced cardiomyopathy, are known to be the most frequent causes of life-threatening events in PPGLs patients.Design: We analysed records of patients diagnosed with PPGLs in one referral centre from Romania between 1976 and 2021 (n= 1...

Thymic hyperplasia is frequent in patients with Graves’ disease (GD) but it rarely is large enough to be detected radiologically as an anterior mediastinal mass. In the few cases operated, lymphoid hyperplasia (i.e. lymphoid follicle proliferation with expansion of both the cortical and the medullary component) has been documented histologically in 38% of cases, while true thymic hyperplasia, i.e. thymic enlargement with normal tissue architecture, was found...

Thymic hyperplasia is frequent in patients with Graves’ disease (GD) but it rarely is large enough to be detected radiologically as an anterior mediastinal mass. In the few cases operated, lymphoid hyperplasia (i.e. lymphoid follicle proliferation with expansion of both the cortical and the medullary component) has been documented histologically in 38% of cases, while true thymic hyperplasia, i.e. thymic enlargement with normal tissue architecture, was found...

Background: Tako-tsubo cardiomyopathy (TTC) is a non-ischemic condition manifested with a temporary weakening of the myocardium after an acute stress. The association between pheochromocytoma (PHEO) and TTC is rare and is attributed to catecholamine excess. We present a case of a young women with an atypical manifestation of PHEO.Clinical case: Patient, F, aged 37, known with multinodular goiter with hypothyroidism for several years, having paroxysmal hy...

Introduction: Primary amenorrhea is defined as the absence of menses at age 15 years in the presence of normal growth and secondary sexual characteristics, or at 13 years, if there is no breast development. We retrospectively assessed the causes of primary amenorrhea in a series from an academic center of adult endocrinology.Patients and methods: We retrieved data from the files of 111 consecutive patients with primary amenorrhea evaluated in our center ...

In acromegaly, treatment with somatostatin analogs (SSA) normalizes growth hormone (GH) and insulin-like growth factor 1 (IGF1) secretion in about half of the patients. Usually, the disease relapses biochemically within few months after treatment withdrawal.We present two acromegalic patients, women of 49 and 53 years at diagnosis, respectively, who achieved stable remission of the disease after medical treatment withdrawal. One had a microadenoma, the o...

Background: Insulinomas, the most common functional neuroendocrine tumours of the pancreas, are usually sporadic, benign and solitary.Aims: To assess biochemical data, localisation and treatment outcome of insulinomas diagnosed in a tertiary endocrine centre.Patients and methods: Twenty-five patients (14 F/11 M), aged 49.1±14.1 years, diagnosed with insulinoma in a Neuroendocrine Tumours centre between 2000 and 2014 were retro...

Introduction: The coexistence of hyperthyroidism and thyroid cancer is rare (below 2% of cases with hyperthyroidism). If this association predisposes to larger, multifocal or more aggressive cancer (especially in Graves’ disease) is a matter of debate. We describe the clinical and hystopathological aspects and evolution in two patients with hyperthyroidism and thyroid cancer.Patient 1, a 42-year-old woman, was diagnosed in 2008 with Graves’ dis...

Introduction: Histiocytosis X is a rare disease involving clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Its manifestations range from isolated bone lesions to multisystem disease. Seen mostly in children, multifocal histiocytosis may involve in 50% of cases the pituitary stalk, leading to diabetes insipidus and usually permanent pituitary deficiencies. We present an adult patient with a com...

Generously supported by IPSEN)-->Treatment with hormone analogues can challenge the precise measurement by interference with the routinely used immunoassays systems, related to the presence of autoantibodies in the serum, interference with associated therapy or the presence of altered forms of the hormone, with modified biological activity and/or immunoreactivity.In patients with acromegaly treated with the hGH...